N,N-Dimethyl-2-Mercaptoethylamine Hydrochloride – Chromatographic Grade™ For Automated Post-Column Derivatization of Primary Amines
Primary amines form highly fluorescent adducts when reacted with o-Phthalaldehyde (OPA) and a mercaptan under basic conditions.
The products of this reaction, 1-alkyl-2-thioalkyl-subsitituted isoindoles, exhibit optimal excitation at 330 nm and maximal emission at 465 nm.
Pickering’s Thiofluor™ 2-(Dimethylamino)ethanethiol HCl, a solid, nearly odorless nucleophile, is a superior substitute for 2-Mercaptoethanol in the preparation of OPA reagents. It forms a more stable reagent and a longer-lasting fluorophore with OPA than does 2-Mercaptoethanol, yet it has the same fluorescence properties.
Unlike the volatile 2-Mercaptoethanol, Thiofluor™ will not migrate through the gas manifold and regulator of the OPA reagent pressurization system.
Two grams of Thiofluor™ 2-(Dimethylamino)ethanethiol HCl is equivalent to 1 mL of 2-Mercaptoethanol.
中文名称 | 柱后衍生试剂 |
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英文名称 | Thiofluor™ 2-(Dimethylamino)ethanethiol HCl |
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